I'm right-handed and use both hands while typing and playing this game - (although I am constantly having to correct myself for typos.)
Anyhow, the pants/shoes thing is intriguing. In skateboarding, surfing, and snowboarding there is a thing called goofy-foot. It refers to one who "leads" with their right foot - those that lead with the left are called regular.
I've only snowboarded once, but one has to be fitted for their stance and your boots are snapped onto the board. Anyhow, I figured I would be regular. I turns out I'm goofy. The whole day I kept spinning around in circles. I've since realized that if I hop on a skateboard, I naturally want to lead with my right...